Protective effect of Celtis tournefortii against copper-induced toxicity in rat liver

This study aimed to investigate the antioxidant and hepatoprotective effects of Celtis tournefortii fruit extract (Ct) against copper-induced liver damage in rats. Thirty-two Wistar Albino rats were divided into four equal groups (n = 8): Control, Copper (Cu), + C. (Cu+Ct), (Ct). Superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) activities, (GSH) concentration, malondialdehyde (MDA), total status (TAS) oxidant (TOS) analysed tissues. Liver histopathology was also evaluated. Alanine aminotransferase lactate dehydrogenase significantly decreased Cu+Ct group compared with Cu group. Oxidative stress parameters MDA TOS increased copper administration, whereas they co-treatment GSH concentration TAS showed significant decreases administration. co-supplementation enhanced such as TAS, SOD, GPx. remarkably attenuated degenerative necrotic changes caused by oral exposure tissue may provide amelioration moderation severity toxicity. The therapeutic use exhibit protective injury treatment.